PIPTO injection
MANUFACTURER/ MARKETER
C Pharmaceuticals
SALT COMPOSITION
Piperacillin (4000mg) + Tazobactum (500mg)
STORAGE
Store below 30°C
Product introduction
PIPTO Injection is a combination of two antibiotics. It is used to treat various types of bacterial infections. It fights against the infection by killing the microorganisms.
PIPTO Injection is generally administered by a healthcare professional and should not be self-administered. Depending on the severity of your underlying illness, your doctor will decide the precise dose and schedule as per which this injection is to be given. It is strictly advised to be used as per the doctor’s prescription.
Some of the common side effects of this medicine include nausea, vomiting, diarrhea, and rash. Additionally, you may notice some injection site reactions like pain, swelling, or redness. You should consult your doctor if these side effects do not get better with time and persist for a longer duration.
Before using the medicine, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. Your doctor may change the dose or prescribe a different medicine. This medicine is generally considered safe to use during pregnancy and breastfeeding if used under a doctor’s supervision.
Uses of PIPTO Injection
Description of PIPTO infections
Definition
Bacterial infections are caused by bacteria, a kind of microorganisms that are made of only one cell. Bacteria live in all kinds of the environment including extreme hot and cold conditions. Millions of bacteria are present in the environment around us, on our body and inside it.
Bacteria are both harmful and useful to us. In fact, only a small number of bacteria are responsible for illnesses. Many are beneficial, such as those involved in immunity, digestion, and production of antibiotics and food products.
Useful Bacteria
Bacteria are important for digestion of food. There are some that fight diseases and those that help make healthful food.
Some examples of good bacteria include:
1. Lactobacillus is used in making yogurt and cheese.
2. Escherichia coli are present in intestines and help in digestion of food, and production of vitamin K.
3. Bacteroides thetaiotaomicron and Bacteroides fragilis live in the gut and help in digestion of carbohydrates and sugar transport and utilization.
Causes and Risk Factors
Some bacteria cause illness. They invade and quickly multiply in the body to form colonies. When this happens in the respiratory tract, the following diseases may occur:
1. Pharyngitis -- Streptococcus pyogenes
2. Diphtheria -- Corynebacterium diphtheria
3. Pertussis -- Bordetella pertussis
4. Tuberculosis -- Mycobacterium tuberculosis
Gastrointestinal infections caused by bacteria include:
1. Peptic ulcers -- Helicobacter pylori
2. Enteric (typhoid) fever -- Salmonella typhi
3. Gastroenteritis -- Shigella, Salmonella, and Escherichia coli
Bacteria cause infections of the nervous system such as:
1. Meningitis -- Streptococcus pneumonia and Neisseria meningitidis
2. Tetanus -- Clostridium tetani
3. Botulism -- Clostridium botulinum
Urogenital infections caused by bacteria include:
1. Urinary tract infections -- Escherichia coli
2. Gonorrhea -- Neisseria gonorrhoeae
3. Chlamydia -- Chlamydia trachomatis
4. Syphilis -- Treponema pallidum
Bacteria also cause skin infections such as:
1. Leprosy -- Mycobacterium leprae
2. Abscess -- Staphylococcus aureus
Signs and Symptoms
The symptoms of bacterial infection would depend on the condition, the organ affected, and the kind of bacteria causing the infection.
Investigations
The diagnosis of bacterial infections would depend on the symptomatic history of the patient. The tests that may be done include:
1. Physical examination
2. Blood tests
3. Urine tests
4. Urine culture
5. Gram stain to identify bacteria
6. Toxin assay to look for the toxins made by the bacteria
7. Culture or biopsy of the tissue infected
Treatment
The treatment will depend on the kind of infection. Antibiotics are usually prescribed to treat bacterial infections. These are medicines that kill the bacteria. They may be given in the oral or injectable form. Some antibiotics that may be prescribed for a bacterial infection may include:
1. Amoxicillin
2. Azithromycin
3. Doxycycline
4. Ofloxacin
5. Tetracycline
6. Gentamycin
7. Metronidazole
8. Clindamycin
Supportive therapy may be required for other symptoms, such as fever.
Complications and When Should You See a Doctor
The complications will depend on the kind of bacterial infection.
Antibiotics must be taken carefully and for the duration, they are prescribed for. Taking them too frequently, taking them without a prescription or not completing the full course of treatment may lead to a development of antibiotic resistance, where antibiotics fail to kill bacteria.
Antibiotic resistance makes treatment of bacterial infections difficult and may prolong the illness and severity.
References
Fernández-Frackelton M. Bacteria. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 9th ed. Philadelphia, PA:Elsevier; 2018:chap 121.
McAdam AJ, Milner DA, Sharpe AH. Infectious diseases. In: Kumar V, Abbas AK, Aster JC, eds. Robbins and Cotran Pathologic Basis of Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap 8.
Benefits of PIPTO Injection
In Bacterial infections
PIPTO Injection contains two different medicines that work together to kill the bacteria that cause infections. Piperacillin belongs to a group of medicines called penicillins that work by stopping the growth of bacteria. Tazobactam is a beta-lactamase inhibitor that reduces resistance and enhances the activity of Piperacillin against bacteria.
Side effects of PIPTO Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of PIPTO
- Nausea
- Vomiting
- Diarrhea
- Rash
- Allergic reaction
How to use PIPTO Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How PIPTO Injection works
PIPTO Injection is a combination of two medicines: Piperacillin and Tazobactum. Piperacillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Tazobactum is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Piperacillin against bacteria.
Safety advice
Consuming alcohol with PIPTO Injection does not cause any harmful side effects.
Pregnancy
SAFE IF PRESCRIBED
PIPTO Injection is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breast feeding
SAFE IF PRESCRIBED
PIPTO Injection is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Driving
CONSULT YOUR DOCTOR
It is not known whether PIPTO Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
PIPTO Injection should be used with caution in patients with kidney disease. Dose adjustment of PIPTO Injection may be needed. Please consult your doctor.
PIPTO Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of PIPTO Injection may not be needed in these patients. Please consult your doctor.
What if you forget to take PIPTO Injection?
If you miss a dose of PIPTO Injection, please consult your doctor.
